The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could cause an increase in methadone plasma concentrations, which could bring about potentially deadly respiratory despair. Moreover, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also lead to an increas